Database building
2. Database Building - Research on Sub-types and on New Resistance Associated Mutations
Since it started its efforts 13 years ago, Virco has created one of the world’s largest databases of HIV genotypes and of correlative HIV genotypes and phenotypes. While these databases contain predominantly clade B viruses, reflecting the history of treatment of the disease, they also contain significant numbers of viruses of non-B clades. Virco is in the process of analyzing mutational patterns among these sub-types.
In addition to analyses of its own databases, Virco collaborates extensively with scientists from different countries in researching individual sub-types predominant in particular geographical areas:
- Sub-type C
- Brazil (Federal Universities of Sao Paulo and Rio de Janeiro),
- Sub-Type AG
- University of Montreal with Hôpital national du Point-G, Bamako, Mali, and CÉSAC
- Sub-Type AE
- Asia (Treat ASIA and TASER initiatives)
- Thailand (Chulalungkorn and Ramathibodi Universities)
Virco’s correlative databases and phenotyping capabilities also enable analyses and validation of the association of new resistance mutations to particular ARV drugs.
Recent publications include:
- Novel Drug Resistance Pattern Associated with the Mutations K70G and M184V in Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Antimicrobial agents and Chemotherapy, Dec. 2007, p. 4489–4491)
- “Phenotypic and clinical impact of HIV-1 protease codon 33 insertions in treatment-experienced patients”; Magali Bouvier-Alias, and Jean-Michel Pawlotsky et al; Laboratoire de virologie, Inserm U841,Creteil,France ; poster accepted for EHDRW 2009, Stockholm.
- “The causes Reduced susceptibility to lamivudine and emtricitabine associated with the novel K66N mutation in HIV-1 reverse transcriptase”; Jorge Villacian, Margriet Van Houtte, Theresa Pattery, et al; Tibotec BVBA ; HIV-9, 9’th International Congress on Drug Therapy in HIV Infection, poster 187, November 2008